Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer.
Wnt signaling plays an important role in colorectal cancer (CRC). Although the mechanisms of β-catenin degradation have been well studied, the mechanism by which β-catenin activates transcription is still not fully understood. While screening a panel of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling. TDG ... interacts with the transcription factor TCF4 and coactivator CREB-binding protein/p300 in the Wnt pathway. Knocking down TDG by shRNAs inhibited the proliferation of CRC cells in vitro and in vivo. In CRC patients, TDG levels were significantly higher in tumor tissues than in the adjacent normal tissues. These results suggest that TDG warrants consideration as a potential biomarker for CRC and as a target for CRC treatment.
Mesh Terms:
Amino Acid Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Peptide Fragments, Protein Transport, Sialoglycoproteins, Sumoylation, Thymine DNA Glycosylase, Transcription Factors, Up-Regulation, Wnt Proteins, Wnt Signaling Pathway
Amino Acid Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Cell Line, Tumor, Cell Proliferation, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Humans, Peptide Fragments, Protein Transport, Sialoglycoproteins, Sumoylation, Thymine DNA Glycosylase, Transcription Factors, Up-Regulation, Wnt Proteins, Wnt Signaling Pathway
J. Biol. Chem.
Date: Mar. 28, 2014
PubMed ID: 24532795
View in: Pubmed Google Scholar
Download Curated Data For This Publication
169858
Switch View:
- Interactions 3