The transcriptional coactivators p300 and CBP are histone acetyltransferases.
p300/CBP is a transcriptional adaptor that integrates signals from many sequence-specific activators via direct interactions. Various cellular and viral factors target p300/CBP to modulate transcription and/or cell cycle progression. One such factor, the cellular p300/CBP associated factor (PCAF), possesses intrinsic histone acetyltransferase activity. Here, we demonstrate that p300/CBP is not ... only a transcriptional adaptor but also a histone acetyltransferase. p300/CBP represents a novel class of acetyltransferases in that it does not have the conserved motif found among various other acetyltransferases. p300/CBP acetylates all four core histones in nucleosomes. These observations suggest that p300/CBP acetylates nucleosomes in concert with PCAF.
Mesh Terms:
Acetylation, Acetyltransferases, Adenoviridae, Amino Acid Sequence, CREB-Binding Protein, Histones, Lysine, Molecular Sequence Data, Nuclear Proteins, Nucleosomes, Phosphorylation, Protein Structure, Tertiary, Trans-Activators, Transcription Factors, Transcription, Genetic, Viral Proteins
Acetylation, Acetyltransferases, Adenoviridae, Amino Acid Sequence, CREB-Binding Protein, Histones, Lysine, Molecular Sequence Data, Nuclear Proteins, Nucleosomes, Phosphorylation, Protein Structure, Tertiary, Trans-Activators, Transcription Factors, Transcription, Genetic, Viral Proteins
Cell
Date: Nov. 29, 1996
PubMed ID: 8945521
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