Acetylation of beta-catenin by CREB-binding protein (CBP).

Acetylation controls the activity of numerous proteins involved in regulating gene transcription as well as many other cellular processes. In this report we show that the CREB-binding protein (CBP) acetyltransferase acetylates beta-catenin protein in vivo. beta-Catenin is a central component of the Wnt signaling pathway, which is of key importance ...
in development as well as being heavily implicated in a variety of human cancers. We show that the CBP-mediated acetylation of beta-catenin occurs at a single site, lysine 49. Importantly, this lysine is frequently found mutated in cancer and is in a region of importance to the regulation of beta-catenin. We show that mutation of this site leads specifically to an increase in the ability of beta-catenin to activate the c-myc gene but not other beta-catenin-regulated genes. This suggests that acetylation of beta-catenin is involved in regulating Wnt signaling in a promoter-specific fashion.
Mesh Terms:
Acetylation, Amino Acid Sequence, Base Sequence, CREB-Binding Protein, Cell Line, Cytoskeletal Proteins, DNA Primers, Humans, Molecular Sequence Data, Nuclear Proteins, Reverse Transcriptase Polymerase Chain Reaction, Trans-Activators, beta Catenin
J. Biol. Chem.
Date: Jul. 12, 2002
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