p300 regulates p63 transcriptional activity.
The transcriptional co-activator p300 has been reported to regulate the tumor suppressor p53 and its ortholog p73. Here we describe a study showing that this coactivator also regulates the transcriptional function of p63. p300 bound to the N-terminal domain of p63gamma, and p63gamma bound to the N terminus of p300 ... in vitro and in cells. p300, but not its acetylase-defective mutant AT2, stimulated p63gamma-dependent transcription and induction of p21 in cells, consequently leading to G1 arrest. Inversely, the deltaN-p63gamma isoform as well as p300AT2 inhibited the induction of p21 by p63gamma. These results suggest that p300 regulates p63-dependent transcription of p21.
Mesh Terms:
Adenoviridae, Cell Cycle, Cell Cycle Proteins, Cell Line, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA-Binding Proteins, Genes, Tumor Suppressor, Glutathione Transferase, Histidine, Humans, Immunoprecipitation, Mutation, Nuclear Proteins, Phosphoproteins, Plasmids, Protein Binding, Protein Structure, Tertiary, Recombinant Fusion Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Transfection, Tumor Suppressor Proteins
Adenoviridae, Cell Cycle, Cell Cycle Proteins, Cell Line, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, DNA-Binding Proteins, Genes, Tumor Suppressor, Glutathione Transferase, Histidine, Humans, Immunoprecipitation, Mutation, Nuclear Proteins, Phosphoproteins, Plasmids, Protein Binding, Protein Structure, Tertiary, Recombinant Fusion Proteins, Trans-Activators, Transcription Factors, Transcription, Genetic, Transcriptional Activation, Transfection, Tumor Suppressor Proteins
J. Biol. Chem.
Date: Aug. 26, 2005
PubMed ID: 15965232
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