c-Abl tyrosine kinase interacts with MAVS and regulates innate immune response.

The tyrosine kinase, c-Abl, plays important roles in many aspects of cellular function. Previous reports showed that c-Abl is involved in NF-kappaB signaling. However, the functions of c-Abl in innate immunity are still unknown. Here we demonstrate that the mitochondrial antiviral signaling (MAVS) protein can be physically associated with c-Abl ...
in vivo and in vitro. MAVS interacted with c-Abl through its Card and TM domain. A phosphotyrosine-specific antibody indicated that MAVS was phosphorylated by c-Abl. Functional impairment of c-Abl attenuated MAVS or VSV induced type-I IFN production. Importantly, c-Abl knockdown in MCF7 cells displayed impaired MAVS-mediated NF-kappaB and IRF3 activation. Taken together, our results suggest that c-Abl modulates innate immune response through MAVS.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Cell Line, Humans, Immunity, Innate, Interferon Regulatory Factor-3, Interferon-beta, NF-kappa B, Phosphorylation, Protein Interaction Domains and Motifs, Protein Interaction Mapping, Proto-Oncogene Proteins c-abl
FEBS Lett.
Date: Jan. 04, 2010
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