Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice.
Chlorpromazine- and haloperidol-induced hypothermia were examined in mice. The alpha 1 receptor agonist phenylephrine partially antagonized the hypothermia, while the dopamine D2 receptor agonist apomorphine did not inhibit it. The central serotonin2 (5-HT2) receptor agonist I-2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) strongly inhibited the chlorpromazine- and haloperidol-induced hypothermia. Both drugs at doses which can ... elicit hypothermia antagonized head twitch responses mediated by the central 5-HT2 receptor. These results suggest that the chlorpromazine- and haloperidol-induced hypothermia may be mediated by the blockade of the central 5-HT2 receptor.
Mesh Terms:
Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-Agonists, Amphetamines, Animals, Apomorphine, Behavior, Animal, Body Temperature, Chlorpromazine, Dopamine Agonists, Dopamine Antagonists, Haloperidol, Hypothermia, Induced, Male, Mice, Mice, Inbred ICR, Phenylephrine, Receptors, Dopamine D2, Serotonin Receptor Agonists
Adrenergic alpha-1 Receptor Agonists, Adrenergic alpha-Agonists, Amphetamines, Animals, Apomorphine, Behavior, Animal, Body Temperature, Chlorpromazine, Dopamine Agonists, Dopamine Antagonists, Haloperidol, Hypothermia, Induced, Male, Mice, Mice, Inbred ICR, Phenylephrine, Receptors, Dopamine D2, Serotonin Receptor Agonists
Biol. Pharm. Bull.
Date: Nov. 01, 1995
PubMed ID: 8593484
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