Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs.
Dual COX/5-LOX (cyclooxygenase/5-lipoxygenase) inhibitors constitute a valuable alternative to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors for the treatment of inflammatory diseases. Indeed, these latter present diverse side effects, which are reduced or absent in dual-acting agents. In this review, COX and 5-LOX pathways are first described in ... order to highlight the therapeutic interest of designing such compounds. Various structural families of dual inhibitors are illustrated.
Mesh Terms:
Animals, Anti-Inflammatory Agents, Non-Steroidal, Arachidonate 5-Lipoxygenase, Binding Sites, Cell Membrane, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Humans, Inflammation, Isoenzymes, Lipoxygenase Inhibitors, Membrane Proteins, Models, Molecular, Prostaglandin-Endoperoxide Synthases, Pyrazoles, Structure-Activity Relationship
Animals, Anti-Inflammatory Agents, Non-Steroidal, Arachidonate 5-Lipoxygenase, Binding Sites, Cell Membrane, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors, Humans, Inflammation, Isoenzymes, Lipoxygenase Inhibitors, Membrane Proteins, Models, Molecular, Prostaglandin-Endoperoxide Synthases, Pyrazoles, Structure-Activity Relationship
Eur J Med Chem
Date: Aug. 23, 2003
PubMed ID: 12932896
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