FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.
The FEZ1/LZTS1 gene maps to chromosome 8p22, a region that is frequently deleted in human tumors. Alterations in FEZ1/LZTS1 expression have been observed in esophageal, breast, and prostate cancers. Here, we show that introduction of FEZ1/LZTS1 into Fez1/Lzts1-negative cancer cells results in suppression of tumorigenicity and reduced cell growth with ... accumulation of cells at late S-G(2)/M stage of the cell cycle. Fez1/Lzts1 protein is hyperphosphorylated by cAMP-dependent kinase during cell-cycle progression. We found that Fez1/Lzts1 is associated with microtubule components and interacts with p34(cdc2) at late S-G(2)/M stage in vivo. Present data show that FEZ1/LZTS1 inhibits cancer cell growth through regulation of mitosis, and that its alterations result in abnormal cell growth.
Mesh Terms:
Adaptor Proteins, Signal Transducing, CDC2 Protein Kinase, Cell Cycle, Cell Division, Chromosomes, Human, Pair 8, DNA-Binding Proteins, Female, Genes, Tumor Suppressor, Humans, Male, Microtubules, Mitosis, Neoplasms, Nerve Tissue Proteins, Peptide Elongation Factor 1, Phosphorylation, Protein Binding, Transfection, Tumor Cells, Cultured, Tumor Suppressor Proteins
Adaptor Proteins, Signal Transducing, CDC2 Protein Kinase, Cell Cycle, Cell Division, Chromosomes, Human, Pair 8, DNA-Binding Proteins, Female, Genes, Tumor Suppressor, Humans, Male, Microtubules, Mitosis, Neoplasms, Nerve Tissue Proteins, Peptide Elongation Factor 1, Phosphorylation, Protein Binding, Transfection, Tumor Cells, Cultured, Tumor Suppressor Proteins
Proc. Natl. Acad. Sci. U.S.A.
Date: Aug. 28, 2001
PubMed ID: 11504921
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