Experimental analyses of synergistic combinations of antibiotics with a recently recognised antibacterial agent, lacidipine.

Department of Microbiology, Herbicure Healthcare Bio-Herbal Research Foundation, 7&8 Metro Garden City, DH Road, Pailan, Kolkata 700104, India.
The cardiovascular drug lacidipine (Lc) is known to possess antibacterial activity. Further potentiation of action is possible by synergism between Lc and an antibiotic or a non-antibiotic. The minimum inhibitory concentration (MIC) of antibiotics, Lc and other non-antibiotics were detected by the agar dilution technique in different bacteria. Synergism was determined by disc diffusion assay, the fractional inhibitory concentration (FIC) index through checkerboard assessment and, also, the protective capacity of the combination by administering the drugs along with 50 x LD(50) challenge dose of virulent Salmonella typhimurium in animal experiments. Synergism between Lc and penicillin was found to be statistically significant (P
Mesh Terms:
Animals, Anti-Bacterial Agents, Colony Count, Microbial, Dihydropyridines, Disease Models, Animal, Drug Synergism, Gram-Negative Bacteria, Gram-Positive Bacteria, Heart, Humans, Liver, Male, Mice, Microbial Sensitivity Tests, Salmonella Infections, Animal, Spleen, Treatment Outcome
Eur. J. Clin. Microbiol. Infect. Dis. Feb. 01, 2010; 29(2);239-43 [PUBMED:20012879]
178957
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