Altered membrane permeability as the basis of bactericidal action of methdilazine.
The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without ... visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
Mesh Terms:
Anti-Bacterial Agents, Biological Transport, Cell Membrane Permeability, Escherichia coli, Glucose, Microbial Sensitivity Tests, Phenothiazines, Potassium, Staphylococcus aureus
Anti-Bacterial Agents, Biological Transport, Cell Membrane Permeability, Escherichia coli, Glucose, Microbial Sensitivity Tests, Phenothiazines, Potassium, Staphylococcus aureus
J. Antimicrob. Chemother.
Date: Jul. 01, 1998
PubMed ID: 9700532
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