Altered membrane permeability as the basis of bactericidal action of methdilazine.

Department of Cellular Biochemistry, Indian Institute of Chemical Biology, Calcutta, India.
The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.
Mesh Terms:
Anti-Bacterial Agents, Biological Transport, Cell Membrane Permeability, Escherichia coli, Glucose, Microbial Sensitivity Tests, Phenothiazines, Potassium, Staphylococcus aureus
J. Antimicrob. Chemother. Jul. 01, 1998; 42(1);83-6 [PUBMED:9700532]
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