Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R

Department of Cellular Biochemistry, Indian Institute of Chemical Biology, Calcutta, India.

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.

Mesh Terms:
Anti-Bacterial Agents, Biological Transport, Cell Membrane Permeability, Escherichia coli, Glucose, Microbial Sensitivity Tests, Phenothiazines, Potassium, Staphylococcus aureus

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