Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis.
Glibenclamide reduced the rate of lesion growth in BALB/c mice infected with Leishmania (Leishmania) mexicana, the effect was dose dependent, and the highest dose proved more effective than glucantime. Cross-resistance to glucantime was found in animals infected with a glibenclamide-resistant line, but combined therapy reduced lesion progression even in the ... glibenclamide-resistant strain.
Mesh Terms:
Adenosine Triphosphate, Animals, Antiprotozoal Agents, Dose-Response Relationship, Drug, Drug Resistance, Glyburide, Leishmania mexicana, Leishmaniasis, Cutaneous, Mice, Mice, Inbred BALB C, Potassium Channel Blockers
Adenosine Triphosphate, Animals, Antiprotozoal Agents, Dose-Response Relationship, Drug, Drug Resistance, Glyburide, Leishmania mexicana, Leishmaniasis, Cutaneous, Mice, Mice, Inbred BALB C, Potassium Channel Blockers
Antimicrob. Agents Chemother.
Date: Dec. 01, 2006
PubMed ID: 17015627
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