LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.

Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss ...
of LAS1 function causes the cells to arrest as 80% unbudded cells and 20% large budded cells that accumulate many vesicles at the mother-daughter neck. Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud. The nuclear localization of LAS1 suggests a role of LAS1 for regulating bud formation and morphogenesis via the expression of components that function directly in these processes.
Mesh Terms:
Amino Acid Sequence, Cell Size, Cell Wall, Fungal Proteins, Genes, Fungal, Mitogen-Activated Protein Kinase Kinases, Molecular Sequence Data, Morphogenesis, Nuclear Proteins, Phosphoprotein Phosphatases, Protein Kinases, Protein Phosphatase 2, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Genetics
Date: Nov. 01, 1995
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