LAS1 is an essential nuclear protein involved in cell morphogenesis and cell surface growth.
Saccharomyces cerevisiae mutations that cause a requirement for SSD1-v for viability were isolated, yielding one new gene, LAS1, and three previously identified genes, SIT4, BCK1/SLK1, and SMP3. Three of these genes, LAS1, SIT4, and BCK1/SLK1, encode proteins that have roles in bud formation or morphogenesis. LAS1 is essential and loss ... of LAS1 function causes the cells to arrest as 80% unbudded cells and 20% large budded cells that accumulate many vesicles at the mother-daughter neck. Overexpression of LAS1 results in extra cell surface projections in the mother cell, alterations in actin and SPA2 localization, and the accumulation of electron-dense structures along the periphery of both the mother cell and the bud. The nuclear localization of LAS1 suggests a role of LAS1 for regulating bud formation and morphogenesis via the expression of components that function directly in these processes.
Mesh Terms:
Amino Acid Sequence, Cell Size, Cell Wall, Fungal Proteins, Genes, Fungal, Mitogen-Activated Protein Kinase Kinases, Molecular Sequence Data, Morphogenesis, Nuclear Proteins, Phosphoprotein Phosphatases, Protein Kinases, Protein Phosphatase 2, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Amino Acid Sequence, Cell Size, Cell Wall, Fungal Proteins, Genes, Fungal, Mitogen-Activated Protein Kinase Kinases, Molecular Sequence Data, Morphogenesis, Nuclear Proteins, Phosphoprotein Phosphatases, Protein Kinases, Protein Phosphatase 2, Recombinant Fusion Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Genetics
Date: Nov. 01, 1995
PubMed ID: 8582632
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