Interleukin-1beta activates a short STAT-3 isoform in clonal insulin-secreting cells.

Clore Laboratory, The University of Buckingham, UK.
Interleukin-1beta (IL-1beta) is a potent inflammatory cytokine involved in type 1 diabetes and acts through defined IL-1beta signaling pathways. In the present work we describe induction of DNA binding activity to signal transducer and activator of transcription (STAT) in response to IL-1beta in clonal insulin-secreting cells. Moreover, IL-1beta activates a short isoform of STAT-3 that potently stimulates transcription. Immunoprecipitation studies reveal an interaction between the activated STAT-3 and the IL-1 receptor accessory protein indicating an association between the two signaling pathways. This may be a novel point of transduction cross talk and an additional mechanism utilised by IL-1beta in the pancreatic beta-cell during the process of type 1 diabetes.
Mesh Terms:
Base Sequence, Clone Cells, DNA, DNA-Binding Proteins, Humans, Insulin, Interleukin-1, Interleukin-1 Receptor Accessory Protein, Islets of Langerhans, Protein Binding, Proteins, Receptors, Interleukin-1, STAT3 Transcription Factor, Signal Transduction, Trans-Activators, Transfection
FEBS Lett. Jan. 08, 1999; 442(1);57-60 [PUBMED:9923604]
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