A procedure for inducing sustained hyperlipemia in rats by administration of a surfactant.
Tyloxapol (Triton WR 1339) is a non-ionic detergent that inhibits lipoprotein lipase and thereby raises levels of serum lipids. It is used frequently for acute studies on lipids in rats but not for subacute or chronic studies. In the present work, we found that tyloxapol must be injected intravenously three ... times each week in order to have high and sustained levels of serum cholesterol and triglycerides for 1, 2, or 3 weeks. These results make it possible to extend the use of tyloxapol into chronic studies of hyperlipemia and vascular disease.
Mesh Terms:
Animals, Cholesterol, Disease Models, Animal, Enzyme Inhibitors, Hyperlipidemias, Injections, Intravenous, Lipoprotein Lipase, Polyethylene Glycols, Rats, Rats, Inbred Lew, Surface-Active Agents, Triglycerides
Animals, Cholesterol, Disease Models, Animal, Enzyme Inhibitors, Hyperlipidemias, Injections, Intravenous, Lipoprotein Lipase, Polyethylene Glycols, Rats, Rats, Inbred Lew, Surface-Active Agents, Triglycerides
J Pharmacol Toxicol Methods
Date: Jul. 15, 2006
PubMed ID: 16839786
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