The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast.

The kinetochore is the macromolecular protein complex that mediates chromosome segregation. The Dsn1 component is crucial for kinetochore assembly and is phosphorylated by the Aurora B kinase. We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast.
Mesh Terms:
Aurora Kinase B, Chromosomal Proteins, Non-Histone, Chromosome Segregation, Gene Expression Regulation, Fungal, Kinetochores, Microtubules, Mitosis, Nuclear Proteins, Phosphorylation, Protein Interaction Maps, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Genetics
Date: Jul. 01, 2013
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