STAT3 acts as a co-activator of glucocorticoid receptor signaling.

Interleukin-6 (IL-6) and glucocorticoids are important mediators of inflammatory and immunological responses. Glucocorticoids are known to synergistically enhance IL-6-mediated cellular responses. We now show that IL-6 also has a synergistic effect upon glucocorticoid signaling. In particular, IL-6-activated STAT3 associates with ligand-bound glucocorticoid receptor to form a transactivating/signaling complex, which can ...
function through either an IL-6-responsive element or a glucocorticoid-responsive element. These findings reveal a new level of interaction between these two crucial signaling cascades and indicate that activated STAT3 can also act as a transcriptional co-activator without direct association with its DNA binding motif.
Mesh Terms:
Animals, COS Cells, DNA-Binding Proteins, Drug Synergism, Glucocorticoids, Interleukin-6, Ligands, Liver Neoplasms, Experimental, Rats, Receptors, Glucocorticoid, STAT3 Transcription Factor, Signal Transduction, Trans-Activators, Transfection, Tumor Cells, Cultured
J. Biol. Chem.
Date: Dec. 05, 1997
Download Curated Data For This Publication
185
Switch View:
  • Interactions 1