Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.
The endoplasmic reticulum (ER) operates in adaptive responses to various stresses, dictating cell fate. Here we show that knockdown of the ER protein mitsugumin23 (MG23) enhances cell death induced by ultraviolet C (UVC), which causes DNA damage. The small heat shock protein αB-crystallin (αBC) is identified as a MG23 binding ... molecule and its knockdown facilitates death of UVC-exposed cells. Conversely, αBC lowered UVC sensitivity when expressed as an ER-anchored form. Taken together, the results suggest that MG23 plays a protective role against UVC by accumulating αBC in the close vicinity of the ER.
Mesh Terms:
Animals, Cell Death, DNA Damage, Endoplasmic Reticulum, Gene Knockdown Techniques, HEK293 Cells, Humans, Membrane Proteins, Mice, Signal Transduction, Ultraviolet Rays, alpha-Crystallin B Chain
Animals, Cell Death, DNA Damage, Endoplasmic Reticulum, Gene Knockdown Techniques, HEK293 Cells, Humans, Membrane Proteins, Mice, Signal Transduction, Ultraviolet Rays, alpha-Crystallin B Chain
FEBS Lett.
Date: May. 02, 2013
PubMed ID: 23542032
View in: Pubmed Google Scholar
Download Curated Data For This Publication
186943
Switch View:
- Interactions 2