Crystal structure of a yeast TFIIA/TBP/DNA complex.
The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and ... bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.
Mesh Terms:
Amino Acid Sequence, Base Sequence, Crystallography, X-Ray, Cytochrome c Group, Cytochromes c, DNA, Fungal, DNA-Binding Proteins, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, Protein Conformation, Recombinant Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, TATA Box, TATA-Box Binding Protein, Transcription Factor TFIIA, Transcription Factors, Transcription, Genetic
Amino Acid Sequence, Base Sequence, Crystallography, X-Ray, Cytochrome c Group, Cytochromes c, DNA, Fungal, DNA-Binding Proteins, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, Protein Conformation, Recombinant Proteins, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, TATA Box, TATA-Box Binding Protein, Transcription Factor TFIIA, Transcription Factors, Transcription, Genetic
Nature
Date: May. 09, 1996
PubMed ID: 8610010
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