Acyclic retinoid inhibits functional interaction of transcription factors Krueppel-like factor 5 and retinoic acid receptor-alpha.
We show that transcription factor Krueppel-like factor 5 (KLF5), which is important in cardiovascular remodeling, interacts with retinoic acid receptor-alpha (RARalpha) to regulate downstream gene expression. Here, we investigated whether acyclic retinoid (ACR) regulates KLF5 and inhibits vascular remodeling. Co-immunoprecipitation and pull-down binding assay showed that ACR attenuates functional interaction ... of KLF5 and RARalpha. ACR affects KLF5 functions by regulating transactivation of platelet-derived growth factor A (PDGF-A) chain. ACR may be a new vascular therapy to target KLF5 in cardiovascular pathology.
Mesh Terms:
Animals, Antineoplastic Agents, Cattle, Cells, Cultured, Immunoprecipitation, Kruppel-Like Transcription Factors, Male, Mice, Mice, Inbred C57BL, Neovascularization, Pathologic, Neovascularization, Physiologic, Receptors, Retinoic Acid, Transcription, Genetic, Tretinoin
Animals, Antineoplastic Agents, Cattle, Cells, Cultured, Immunoprecipitation, Kruppel-Like Transcription Factors, Male, Mice, Mice, Inbred C57BL, Neovascularization, Pathologic, Neovascularization, Physiologic, Receptors, Retinoic Acid, Transcription, Genetic, Tretinoin
FEBS Lett.
Date: May. 28, 2008
PubMed ID: 18466769
View in: Pubmed Google Scholar
Download Curated Data For This Publication
188331
Switch View:
- Interactions 2