Characterization of two distinct DP-related genes from Arabidopsis thaliana.

E2F/DP complexes play a pivotal role in the regulation of the G1/S transition in animals. Recently, plant E2F homologs have been cloned, but DP-related sequences have not been identified so far. Here we report that Arabidopsis thaliana contains at least two different DP-related genes, AtDPa and AtDPb. They exhibit an ...
overall domain organization similar to that of their animal counterparts, although phylogenetic analysis demonstrated that they form a separate subgroup. AtDPs efficiently heterodimerize in vitro with the Arabidopsis E2F-related proteins, AtE2Fa and AtE2Fb through their dimerization domains. AtDPa and AtE2Fa are predominantly produced in actively dividing cells with highest transcript levels in early S phase cells.
Mesh Terms:
Amino Acid Sequence, Animals, Arabidopsis, Binding Sites, Carrier Proteins, Cell Cycle, Cell Cycle Proteins, DNA-Binding Proteins, Dimerization, E2F Transcription Factors, Gene Expression Regulation, Plant, Genes, Plant, Humans, Molecular Sequence Data, Mutation, Organ Specificity, Phylogeny, Plant Proteins, Precipitin Tests, Protein Binding, Protein Structure, Tertiary, RNA, Messenger, RNA, Plant, Retinoblastoma-Binding Protein 1, Sequence Alignment, Transcription Factor DP1, Transcription Factors, Two-Hybrid System Techniques
FEBS Lett.
Date: Dec. 01, 2000
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