Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation.

Meiosis is a specialized cell division in which two chromosome segregation phases follow a single DNA replication phase. The budding yeast Polo-like kinase Cdc5 was found to be instrumental in establishing the meiosis I chromosome segregation program. Cdc5 was required to phosphorylate and remove meiotic cohesin from chromosomes. Furthermore, in ...
the absence of CDC5 kinetochores were bioriented during meiosis I, and Mam1, a protein essential for coorientation, failed to associate with kinetochores. Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5.
Mesh Terms:
Anaphase, Cell Cycle Proteins, Cell Nucleus, Centromere, Chromatids, Chromosome Segregation, Chromosomes, Fungal, Kinetochores, Meiosis, Metaphase, Nuclear Proteins, Phosphorylation, Protein Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Science
Date: Apr. 18, 2003
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