TRAF4 participates in Wnt/β-catenin signaling in breast cancer by upregulating β-catenin and mediating its translocation to the nucleus.

Tumor necrosis factor receptor-associated factor 4 (TRAF4) is upregulated in various subtypes of breast cancers and cell lines; however, the precise functions of TRAF4 are poorly understood. Our objective was to investigate its relationship with β-catenin. TRAF4 participates in several signaling pathways, such as NF-κB and JNK signaling pathways. In ...
this study, we identified β-catenin as a TRAF4-binding protein, have shown that TRAF4 enhanced expression of β-catenin, and found that TRAF4 mediated the translocation of β-catenin from the cytoplasm to the nucleus, thereby facilitating activation of the Wnt signaling pathway in breast cancer.
Mesh Terms:
Active Transport, Cell Nucleus, Breast Neoplasms, Cell Line, Tumor, Cell Nucleus, Female, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, TNF Receptor-Associated Factor 4, Up-Regulation, Wnt Signaling Pathway, beta Catenin
Mol. Cell. Biochem.
Date: Oct. 01, 2014
Download Curated Data For This Publication
191039
Switch View:
  • Interactions 2