The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast.
The Mre11p/Rad50p/Xrs2p complex is involved in the repair of double-strand DNA breaks, nonhomologous end joining, and telomere length regulation. TEL1 is primarily involved in telomere length regulation. By an epistasis analysis, we conclude that Tel1p and the Mre11p/Rad50p/Xrs2p complex function in a single pathway of telomere length regulation.
Mesh Terms:
DNA-Binding Proteins, Endodeoxyribonucleases, Exodeoxyribonucleases, Fungal Proteins, Intracellular Signaling Peptides and Proteins, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction, Telomere
DNA-Binding Proteins, Endodeoxyribonucleases, Exodeoxyribonucleases, Fungal Proteins, Intracellular Signaling Peptides and Proteins, Protein-Serine-Threonine Kinases, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction, Telomere
Genetics
Date: May. 01, 2000
PubMed ID: 10790418
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