RAD58 (XRS4)--a new gene in the RAD52 epistasis group.

The RAD58 (XRS4) gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that RAD58 also encodes an essential meiotic function. The spore inviability of rad58 strains is not rescued by a spo13 mutation. The rad50 mutation suppresses spore inviability of a ...
spo13 rad58 strain suggesting that RAD58 acts after RAD50 in meiotic recombination. The rad58-4 mutation does not prevent mitotic recombination events. Haploid rad58 cells fail to carry out G2-repair of gamma-induced lesions, whereas rad58/rad58 diploids are able to perform some diploid-specific repair of these lesions.
Mesh Terms:
DNA Damage, DNA Repair, DNA, Fungal, Epistasis, Genetic, Fungal Proteins, Gamma Rays, Genes, Fungal, Genetic Complementation Test, Meiosis, Plasmids, Ploidies, Recombination, Genetic, Reproduction, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
Curr. Genet.
Date: Aug. 01, 1995
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