PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction.
The promyelocytic leukemia protein PML acts as a tumor suppressor by forming transcription-regulatory complexes with a variety of repressor proteins. In the present study, we found that endogenous PML suppresses interleukin (IL)-6-induced gene expression as well as phosphorylation and transcriptional activation of STAT3 in hepatoma cells. We also found that ... PML-mediated suppression of IL-6-induced STAT3 activation by disrupting interactions between STAT3 and HDAC3. These results indicate that PML modulates IL-6-induced STAT3 activation and hepatoma cell growth by interacting with HDAC3.
Mesh Terms:
Carcinoma, Hepatocellular, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Histone Deacetylases, Humans, Interleukin-6, Liver Neoplasms, Nuclear Proteins, Protein Interaction Maps, STAT3 Transcription Factor, Transcription Factors, Transcriptional Activation, Tumor Suppressor Proteins
Carcinoma, Hepatocellular, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Histone Deacetylases, Humans, Interleukin-6, Liver Neoplasms, Nuclear Proteins, Protein Interaction Maps, STAT3 Transcription Factor, Transcription Factors, Transcriptional Activation, Tumor Suppressor Proteins
Biochem. Biophys. Res. Commun.
Date: May. 29, 2015
PubMed ID: 25892518
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