The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.

Herpes simplex virus 1 (HSV-1) is the most prevalent human virus and causes global morbidity because the virus is able to infect multiple cell types. Remarkably, HSV infection switches between lytic and latent cycles, where T cells play a critical role. However, the precise way of virus-host interactions is incompletely ...
understood. Here we report that HSV-1 productively infected Jurkat T-cells and inhibited antigen-induced T cell receptor activation. We discovered that HSV-1-encoded Us3 protein interrupted TCR signaling and interleukin-2 production by inactivation of the linker for activation of T cells. This study unveils a mechanism by which HSV-1 intrudes into early events of TCR-mediated cell signaling and may provide novel insights into HSV infection, during which the virus escapes from host immune surveillance.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Herpes Simplex, Herpesvirus 1, Human, Humans, Immune Evasion, Interleukin-2, Jurkat Cells, Membrane Proteins, Protein-Serine-Threonine Kinases, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, TNF Receptor-Associated Factor 6, Viral Proteins
J. Biol. Chem.
Date: Jun. 19, 2015
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