Complete, 12-subunit RNA polymerase II at 4.1-A resolution: implications for the initiation of transcription.
The x-ray structure of complete RNA polymerase II from Saccharomyces cerevisiae has been determined, including a heterodimer of subunits Rpb4 and Rpb7 not present in previous "core" polymerase II structures. The heterodimer maintains the polymerase in the conformation of a transcribing complex, may bind RNA as it emerges from the ... enzyme, and is in a position to interact with general transcription factors and the Mediator of transcriptional regulation.
Mesh Terms:
Catalytic Domain, Crystallography, X-Ray, Models, Molecular, Molecular Structure, Protein Structure, Quaternary, Protein Subunits, RNA Polymerase II, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Static Electricity, Transcription, Genetic
Catalytic Domain, Crystallography, X-Ray, Models, Molecular, Molecular Structure, Protein Structure, Quaternary, Protein Subunits, RNA Polymerase II, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Static Electricity, Transcription, Genetic
Proc. Natl. Acad. Sci. U.S.A.
Date: Jun. 10, 2003
PubMed ID: 12746498
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