Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle.

Sub1 and Maf1 exert an opposite effect on RNA polymerase III transcription interfering with different steps of the transcription cycle. In this study, we present evidence that Sub1 and Maf1 also exhibit an opposite role on yeast chronological life span. First, cells lacking Sub1 need more time than wild type ...
to exit from resting and this lag in re-proliferation is correlated with a delay in transcriptional reactivation. Second, our data show that the capacity of the cells to properly establish a quiescent state is impaired in the absence of Sub1 resulting in a premature death that is dependent on the Ras/PKA and Tor1/Sch9 signalling pathways. On the other hand, we show that maf1Δ cells are long-lived mutant suggesting a connection between Pol III transcription and yeast longevity.
Mesh Terms:
Cell Cycle, Cell Proliferation, Cell Survival, Cyclic AMP-Dependent Protein Kinases, DNA-Binding Proteins, Longevity, Phosphatidylinositol 3-Kinases, Protein-Serine-Threonine Kinases, RNA Polymerase III, Reactive Oxygen Species, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction, Transcription Factors, Transcriptional Activation, ras Proteins
PLoS ONE
Date: Dec. 23, 2014
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