Either one of the two yeast EF-1 alpha genes is required for cell viability.

Two genes, TEF1 and TEF2, encode the protein elongation factor EF-1 alpha in the yeast Saccharomyces cerevisiae. We have generated yeast haploid strains containing either TEF1 or TEF2 interrupted by insertion of a large piece of foreign DNA. Cells which contain either one functional copy of the EF-1 alpha genes ...
are viable. In contrast, attempts to isolate a yeast haploid strain with both TEF1 and TEF2 inactivated have failed suggesting that the double gene disruption is a lethal event.
Mesh Terms:
Genes, Genes, Fungal, Peptide Elongation Factor 1, Peptide Elongation Factors, Saccharomyces cerevisiae
Curr. Genet.
Date: Jan. 01, 1985
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