Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.

Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe homologue are closely related to several human ...
genes, including one associated with acute myeloid leukaemia arising from the recurrent translocation t(8;16)(p11;p13) and one implicated in HIV-1 Tat interactions. All of these genes encode proteins with an atypical zinc finger and well-conserved similarities to acetyltransferases. Sequence similarities and yeast mutant phenotypes suggest that SAS-like genes function in transcriptional regulation and cell-cycle exit and reveal novel connections between transcriptional silencing and human disease.
Mesh Terms:
Acetyltransferases, Acute Disease, Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA, Fungal, Enhancer Elements, Genetic, Fungal Proteins, G0 Phase, Gene Expression Regulation, Fungal, Gene Products, tat, HIV-1, Humans, Leukemia, Myeloid, Molecular Sequence Data, Mutation, Phenotype, Saccharomyces cerevisiae, Schizosaccharomyces, Sequence Homology, Amino Acid, Silent Information Regulator Proteins, Saccharomyces cerevisiae, Trans-Activators, Zinc Fingers, tat Gene Products, Human Immunodeficiency Virus
Nat. Genet.
Date: Sep. 01, 1996
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