Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase.
The cytochrome c oxidase (COX) is the terminal enzyme of the respiratory chain. The complex accepts electrons from cytochrome c and passes them onto molecular oxygen. This process contributes to energy capture in the form of a membrane potential across the inner membrane. The enzyme complex assembles in a stepwise ... process from the three mitochondria-encoded core subunits Cox1, Cox2 and Cox3, which associate with nuclear-encoded subunits and cofactors. In the yeast Saccharomyces cerevisiae, the cytochrome c oxidase associates with the bc1-complex into supercomplexes, allowing efficient energy transduction. Here we report on Cox26 as a protein found in respiratory chain supercomplexes containing cytochrome c oxidase. Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization.
Mesh Terms:
Electron Transport Complex IV, Membrane Potential, Mitochondrial, Mitochondria, Mitochondrial Membranes, Oxygen Consumption, Protein Subunits, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Time Factors
Electron Transport Complex IV, Membrane Potential, Mitochondrial, Mitochondria, Mitochondrial Membranes, Oxygen Consumption, Protein Subunits, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Time Factors
Biochim. Biophys. Acta
Date: Jul. 01, 2016
PubMed ID: 27083394
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