Mus musculus
BAX
BCL2-associated X protein
GO Process (107)
GO Function (11)
GO Component (18)
Gene Ontology Biological Process
- B cell apoptotic process [IGI, ISO]
- B cell homeostasis [IGI, IMP]
- B cell homeostatic proliferation [IMP]
- B cell negative selection [IGI]
- B cell receptor apoptotic signaling pathway [ISO]
- Sertoli cell proliferation [IGI]
- T cell homeostatic proliferation [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, IGI, IMP, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [IDA, IMP, ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- apoptotic mitochondrial changes [IDA, ISO]
- apoptotic process [IDA, IMP, ISO]
- apoptotic process involved in embryonic digit morphogenesis [IGI]
- apoptotic process involved in patterning of blood vessels [IGI]
- apoptotic signaling pathway [IMP, ISO]
- blood vessel remodeling [IGI]
- cell proliferation [IDA, IGI]
- cellular respiration [ISO]
- cellular response to DNA damage stimulus [IMP]
- cellular response to UV [IGI]
- cellular response to organic substance [IDA]
- cerebral cortex development [IMP]
- development of secondary sexual characteristics [IMP]
- ectopic germ cell programmed cell death [IGI, IMP]
- establishment or maintenance of transmembrane electrochemical gradient [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- fertilization [IGI]
- germ cell development [IGI]
- glycosphingolipid metabolic process [IMP]
- homeostasis of number of cells [IGI, IMP]
- homeostasis of number of cells within a tissue [IMP]
- hypothalamus development [IMP]
- inner mitochondrial membrane organization [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- intrinsic apoptotic signaling pathway by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IGI, ISO]
- kidney development [IGI]
- leukocyte homeostasis [IGI]
- limb morphogenesis [IGI]
- male gonad development [IGI, IMP]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- mitochondrial fusion [IGI, ISO]
- mitochondrion morphogenesis [IGI]
- myeloid cell homeostasis [IGI]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of cell proliferation [IMP]
- negative regulation of endoplasmic reticulum calcium ion concentration [IGI]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of peptidyl-serine phosphorylation [IGI]
- negative regulation of protein binding [ISO]
- nervous system development [IMP]
- neuron apoptotic process [IGI, IMP]
- neuron migration [IMP]
- odontogenesis of dentin-containing tooth [IGI]
- outer mitochondrial membrane organization [ISO]
- ovarian follicle development [IGI, IMP]
- positive regulation of B cell apoptotic process [IGI]
- positive regulation of apoptotic DNA fragmentation [ISO]
- positive regulation of apoptotic process [IDA, IGI, IMP, ISO]
- positive regulation of apoptotic process involved in mammary gland involution [IMP]
- positive regulation of calcium ion transport into cytosol [IGI]
- positive regulation of developmental pigmentation [IGI]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- positive regulation of intrinsic apoptotic signaling pathway [IMP, ISO]
- positive regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- positive regulation of neuron apoptotic process [IGI, IMP, ISO]
- positive regulation of protein oligomerization [ISO]
- positive regulation of release of cytochrome c from mitochondria [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [IMP]
- post-embryonic camera-type eye morphogenesis [IGI]
- post-embryonic development [IGI]
- protein homooligomerization [IDA, ISO]
- protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [IMP]
- protein oligomerization [ISO]
- regulation of cell cycle [IGI]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- regulation of mammary gland epithelial cell proliferation [IMP]
- regulation of mitochondrial membrane permeability involved in apoptotic process [IGI]
- regulation of mitochondrial membrane permeability involved in programmed necrotic cell death [IMP]
- regulation of mitochondrial membrane potential [IDA]
- regulation of neuron apoptotic process [IMP]
- regulation of nitrogen utilization [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- release of cytochrome c from mitochondria [IDA, IGI, ISO]
- release of matrix enzymes from mitochondria [ISO]
- response to axon injury [IMP]
- response to gamma radiation [IMP]
- response to ionizing radiation [IGI, IMP]
- response to salt stress [IGI]
- response to toxic substance [IMP, ISO]
- response to wounding [IMP]
- retina development in camera-type eye [IMP]
- retinal cell apoptotic process [ISO]
- retinal cell programmed cell death [IMP]
- sex differentiation [IMP]
- spermatid differentiation [IMP]
- spermatogenesis [IGI, IMP]
- thymocyte apoptotic process [IGI]
- transformed cell apoptotic process [ISO]
- transmembrane transport [IBA]
- vagina development [IGI]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [IBA, ISO]
- chaperone binding [ISO]
- heat shock protein binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IMP, IPI, ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [IBA, ISO]
- chaperone binding [ISO]
- heat shock protein binding [ISO]
- identical protein binding [ISO]
- lipid binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IMP, IPI, ISO]
Gene Ontology Cellular Component
- BAX complex [IPI, ISO]
- Bcl-2 family protein complex [ISO]
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISS]
- intracellular [IDA, IGI]
- membrane [ISO]
- mitochondrial membrane [IDA, ISO]
- mitochondrial outer membrane [IDA, ISO]
- mitochondrial permeability transition pore complex [ISO]
- mitochondrion [IDA, IGI, ISO]
- nuclear envelope [ISO]
- nucleus [ISO]
- pore complex [ISO]
Download Curated Data for this Protein
198304
10090
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- Interactors 24
- Interactions 35
- Network
- PTM Sites 4