Mus musculus
BCL2
AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik
B cell leukemia/lymphoma 2
GO Process (135)
GO Function (13)
GO Component (14)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- B cell homeostasis [IMP]
- B cell lineage commitment [IMP]
- B cell proliferation [ISO]
- B cell receptor signaling pathway [ISO]
- CD8-positive, alpha-beta T cell lineage commitment [IMP]
- T cell differentiation [IMP]
- T cell differentiation in thymus [IMP]
- T cell homeostasis [IGI, IMP]
- T cell lineage commitment [IMP]
- actin filament organization [IMP]
- apoptotic mitochondrial changes [IDA]
- apoptotic process [IMP, ISO]
- axon regeneration [IDA]
- axonogenesis [IMP]
- behavioral fear response [IMP]
- branching involved in ureteric bud morphogenesis [IDA, IGI]
- cell aging [IMP]
- cell growth [IMP]
- cell morphogenesis [IMP]
- cell proliferation [IGI]
- cellular calcium ion homeostasis [IDA]
- cellular response to DNA damage stimulus [ISO]
- cellular response to glucose starvation [IDA]
- cellular response to hypoxia [IDA]
- cellular response to organic substance [IDA]
- cochlear nucleus development [IMP]
- defense response to virus [ISO]
- developmental growth [IMP]
- developmental pigmentation [IGI, IMP]
- digestive tract morphogenesis [IMP]
- ear development [IGI, IMP]
- endoplasmic reticulum calcium ion homeostasis [IGI]
- extrinsic apoptotic signaling pathway in absence of ligand [IGI]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- focal adhesion assembly [IMP]
- gland morphogenesis [IMP]
- glomerulus development [IMP]
- growth [IMP]
- hair follicle morphogenesis [IMP]
- hemopoiesis [IMP]
- homeostasis of number of cells within a tissue [IMP]
- immune system development [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage [IBA]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- intrinsic apoptotic signaling pathway in response to oxidative stress [IMP]
- kidney development [IGI, IMP]
- leukocyte homeostasis [IMP]
- lymphocyte homeostasis [IGI, IMP]
- lymphoid progenitor cell differentiation [IMP]
- male gonad development [IGI]
- melanin metabolic process [IMP]
- melanocyte differentiation [IGI, IMP]
- mesenchymal cell development [IMP]
- metanephros development [IMP]
- negative regulation of G1/S transition of mitotic cell cycle [IDA, IMP]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IDA, IGI, IMP, ISO, ISS]
- negative regulation of apoptotic signaling pathway [IDA, ISO]
- negative regulation of calcium ion transport into cytosol [IGI]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of cellular pH reduction [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of myeloid cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IDA, IMP, ISO]
- negative regulation of ossification [IMP]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of retinal cell programmed cell death [IMP]
- neuron apoptotic process [IGI, IMP]
- oocyte development [IMP]
- organ growth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- ovarian follicle development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- pigment granule organization [IMP]
- pigmentation [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of catalytic activity [IMP]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IDA]
- positive regulation of developmental pigmentation [IGI, IMP]
- positive regulation of melanocyte differentiation [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of neuron maturation [IMP]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- post-embryonic development [IGI, IMP]
- protein dephosphorylation [IDA]
- protein polyubiquitination [ISO]
- reactive oxygen species metabolic process [IMP]
- regulation of apoptotic process [IGI]
- regulation of calcium ion transport [ISO]
- regulation of catalytic activity [IMP]
- regulation of cell cycle [IMP]
- regulation of cell-matrix adhesion [IMP]
- regulation of developmental pigmentation [IGI]
- regulation of gene expression [IMP]
- regulation of glycoprotein biosynthetic process [IMP]
- regulation of mitochondrial membrane permeability [IDA]
- regulation of mitochondrial membrane potential [IDA]
- regulation of nitrogen utilization [IGI]
- regulation of programmed cell death [IGI]
- regulation of protein heterodimerization activity [ISO]
- regulation of protein homodimerization activity [ISO]
- regulation of protein localization [IMP]
- regulation of protein stability [IMP]
- regulation of transmembrane transporter activity [ISO]
- regulation of viral genome replication [IDA]
- release of cytochrome c from mitochondria [IDA]
- renal system process [IMP]
- response to UV-B [IMP]
- response to acid chemical [IDA]
- response to cytokine [IMP, ISO]
- response to drug [IDA, ISO]
- response to gamma radiation [IMP]
- response to glucocorticoid [IDA, IMP]
- response to hydrogen peroxide [IMP]
- response to iron ion [ISO]
- response to ischemia [IMP]
- response to nicotine [ISO]
- response to oxidative stress [IMP]
- response to steroid hormone [IMP]
- response to toxic substance [IMP, ISO]
- single organismal cell-cell adhesion [IMP]
- spleen development [IGI, IMP]
- thymus development [IGI, IMP]
- transmembrane transport [ISO]
- ureteric bud development [IMP]
Gene Ontology Molecular Function- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- BH domain binding [ISO]
- BH3 domain binding [ISO]
- channel activity [ISO]
- channel inhibitor activity [ISO]
- identical protein binding [ISO]
- protease binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI, ISO]
- protein homodimerization activity [IBA, ISO]
- protein phosphatase 2A binding [IDA]
- protein phosphatase binding [IDA]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- cell [IGI]
- cytoplasm [IDA, ISO]
- cytosol [IDA]
- endoplasmic reticulum [IDA, IGI, ISO]
- endoplasmic reticulum membrane [IDA]
- intracellular [IDA, IMP]
- membrane [IDA, ISO]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [IBA, ISO]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nuclear membrane [IDA, ISO]
- nucleus [IDA, ISO]
- pore complex [ISO]
Download Curated Data for this Protein
198318
10090
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- Interactors 33
- Interactions 49
- Network
- PTM Sites 1