Mus musculus
CDKN2A
ARF-INK4a, Arf, INK4a-ARF, Ink4a/Arf, MTS1, Pctr1, p16, p16(INK4a), p16INK4a, p19, p19ARF, RP23-166I8.5
cyclin-dependent kinase inhibitor 2A
GO Process (57)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- aging [IMP]
- apoptotic mitochondrial changes [ISO]
- cell aging [IDA]
- cell cycle arrest [IDA, ISO]
- cellular response to hydrogen peroxide [IDA]
- cellular senescence [IDA, ISO]
- epidermis development [IMP]
- glucose homeostasis [IMP]
- negative regulation of B cell proliferation [IMP]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cell cycle [IDA]
- negative regulation of cell growth [IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA, ISO]
- negative regulation of immature T cell proliferation in thymus [IMP]
- negative regulation of mammary gland epithelial cell proliferation [IMP]
- negative regulation of phosphorylation [ISO]
- negative regulation of protein binding [IDA]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of proteolysis involved in cellular protein catabolic process [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of ubiquitin-protein transferase activity [IDA]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IC, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of apoptotic process involved in mammary gland involution [IMP]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of cellular senescence [ISO]
- positive regulation of macrophage apoptotic process [IGI]
- positive regulation of protein sumoylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IMP]
- positive regulation of smooth muscle cell apoptotic process [IGI]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein destabilization [ISO]
- protein polyubiquitination [ISO]
- protein stabilization [ISO]
- rRNA transcription [IGI]
- regulation of G2/M transition of mitotic cell cycle [ISO]
- regulation of apoptotic DNA fragmentation [ISO]
- regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- regulation of gene expression [IMP]
- regulation of nucleocytoplasmic transport [IGI]
- regulation of protein export from nucleus [ISO]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
- replicative senescence [ISO]
- response to drug [ISO]
- response to organic cyclic compound [ISO]
- response to organonitrogen compound [ISO]
- senescence-associated heterochromatin focus assembly [ISO]
- somatic stem cell division [IMP]
- somatic stem cell maintenance [IGI]
Gene Ontology Molecular Function- MDM2/MDM4 family protein binding [ISO]
- NF-kappaB binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA, ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO]
- ubiquitin-protein transferase inhibitor activity [IDA]
- MDM2/MDM4 family protein binding [ISO]
- NF-kappaB binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA, ISO]
- p53 binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [ISO]
- ubiquitin-protein transferase inhibitor activity [IDA]
Gene Ontology Cellular Component
Download Curated Data for this Protein
198654
10090
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- Interactors 46
- Interactions 76
- Network
- PTM Sites 1