A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.
We isolated a novel rad52 mutation, rad52-L89F, which specifically impairs recombination in rad51Delta cells. rad52-L89F displays phenotypes similar to rad59Delta and encodes a mutant protein impaired in its ability to interact with Rad59. These results support the idea that Rad59 acts in homologous recombination via physical interaction with Rad52.
Mesh Terms:
Amino Acid Sequence, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Methyl Methanesulfonate, Molecular Sequence Data, Mutation, Rad51 Recombinase, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Alignment
Amino Acid Sequence, DNA-Binding Proteins, Electrophoresis, Polyacrylamide Gel, Methyl Methanesulfonate, Molecular Sequence Data, Mutation, Rad51 Recombinase, Rad52 DNA Repair and Recombination Protein, Recombination, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Alignment
Genetics
Date: Sep. 01, 2004
PubMed ID: 15454565
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