Mus musculus
CD74
CLIP, DHLAG, HLADG, Ia-GAMMA, Ii
CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
GO Process (35)
GO Function (10)
GO Component (17)
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- antigen processing and presentation [IDA, IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- cell proliferation [ISO]
- chaperone mediated protein folding requiring cofactor [IDA, IMP]
- cytokine-mediated signaling pathway [IMP]
- defense response [IMP]
- immunoglobulin mediated immune response [IMP]
- intracellular protein transport [IDA, IMP]
- macrophage migration inhibitory factor signaling pathway [IDA]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IMP, ISO]
- negative regulation of T cell differentiation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP, ISO]
- negative regulation of mature B cell apoptotic process [IMP]
- negative regulation of peptide secretion [ISO]
- negative thymic T cell selection [IMP]
- positive regulation of B cell proliferation [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of T cell differentiation [IMP]
- positive regulation of adaptive immune response [NAS]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [IDA]
- positive regulation of cytokine-mediated signaling pathway [IMP, ISO]
- positive regulation of dendritic cell antigen processing and presentation [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of innate immune response [IC]
- positive regulation of macrophage cytokine production [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of type 2 immune response [IMP]
- positive thymic T cell selection [IMP]
- prostaglandin biosynthetic process [ISO]
- protein complex assembly [IDA]
- protein folding [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
- MHC class II protein binding [IPI]
- MHC class II protein binding, via antigen binding groove [ISO]
- MHC class II protein complex binding [ISO]
- beta-amyloid binding [ISO]
- cytokine binding [IDA, ISO]
- cytokine receptor activity [IMP, ISO]
- macrophage migration inhibitory factor binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- MHC class II protein complex [IDA]
- NOS2-CD74 complex [IDA]
- cell surface [ISO]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [ISO]
- integral component of plasma membrane [TAS]
- intracellular [IMP]
- late endosome [IDA]
- lysosome [IDA]
- macrophage migration inhibitory factor receptor complex [IDA, ISO]
- membrane [ISO]
- multivesicular body [IDA]
- plasma membrane [IDA, IMP]
- vacuole [ISO]
Download Curated Data for this Protein
200600
10090
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- Interactors 2
- Interactions 2
- Network