Mus musculus
SMAD2
7120426M23Rik, Madh2, Madr2, Smad-2, mMad2
SMAD family member 2
GO Process (45)
GO Function (20)
GO Component (9)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [IMP]
- cell fate commitment [IMP]
- common-partner SMAD protein phosphorylation [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- endoderm formation [IMP]
- gastrulation [IGI]
- heart development [IGI]
- in utero embryonic development [IGI, IMP]
- insulin secretion [IGI]
- intracellular signal transduction [IDA, ISO]
- lung development [IGI]
- mesoderm formation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- nodal signaling pathway [ISO]
- organ growth [IGI]
- palate development [IMP]
- pancreas development [IGI]
- paraxial mesoderm morphogenesis [IMP]
- pattern specification process [IGI]
- pericardium development [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, IMP, ISO]
- post-embryonic development [IGI]
- protein phosphorylation [IDA, ISS]
- regulation of binding [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- response to cholesterol [ISO]
- response to glucose [IGI]
- signal transduction involved in regulation of gene expression [ISO]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, IGI, ISO]
- zygotic specification of dorsal/ventral axis [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- DNA binding [ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- SMAD binding [IPI, ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- double-stranded DNA binding [IDA]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription factor binding [IPI, ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- type I transforming growth factor beta receptor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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10090
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- Interactors 34
- Interactions 43
- Network
- PTM Sites 1