Mus musculus
SMAD4
AW743858, D18Wsu70e, DPC4, Madh4
SMAD family member 4
GO Process (54)
GO Function (23)
GO Component (10)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [ISO]
- anterior/posterior pattern specification [IMP]
- atrioventricular canal development [IGI]
- atrioventricular valve formation [IGI]
- axon guidance [IMP]
- brainstem development [IMP]
- branching involved in ureteric bud morphogenesis [IGI]
- cardiac septum development [IGI]
- cell proliferation [IMP]
- developmental growth [IMP]
- endocardial cell differentiation [IMP]
- endoderm development [IMP]
- endothelial cell activation [IMP]
- epithelial to mesenchymal transition involved in endocardial cushion formation [IMP]
- formation of anatomical boundary [IMP]
- gastrulation [IMP]
- gastrulation with mouth forming second [IMP]
- in utero embryonic development [IMP]
- intracellular signal transduction [ISO]
- kidney development [IMP]
- mesoderm development [IMP]
- metanephric mesenchyme morphogenesis [IMP]
- negative regulation of cell death [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of protein catabolic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- nephrogenic mesenchyme morphogenesis [IMP]
- neural crest cell differentiation [IMP]
- neuron fate commitment [IMP]
- palate development [IMP]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of SMAD protein import into nucleus [IMP]
- positive regulation of cell proliferation involved in heart valve morphogenesis [IMP]
- positive regulation of epithelial to mesenchymal transition [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of binding [IDA]
- regulation of cell proliferation [IGI, IMP]
- regulation of hair follicle development [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- response to transforming growth factor beta [ISO]
- sebaceous gland development [IMP]
- somite rostral/caudal axis specification [IMP]
- tissue morphogenesis [IMP]
- transcription from RNA polymerase II promoter [ISO]
- transforming growth factor beta receptor signaling pathway [IGI, ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- chromatin binding [IDA]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- filamin binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [ISO]
- DNA binding [IDA, ISO]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription factor binding [IPI]
- RNA polymerase II transcription factor binding transcription factor activity [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [ISO]
- chromatin binding [IDA]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- filamin binding [ISO]
- identical protein binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor, common-partner cytoplasmic mediator activity [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
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- Interactors 33
- Interactions 51
- Network
- PTM Sites 1