Drep-2 is a novel synaptic protein important for learning and memory.
CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input ... synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.
Mesh Terms:
Animals, Apoptosis, Conditioning (Psychology), Drosophila Proteins, Drosophila melanogaster, Fragile X Mental Retardation Protein, Mass Spectrometry, Memory, Mushroom Bodies, Mutation, Neurons, Phenotype, Post-Synaptic Density, Receptors, Metabotropic Glutamate, Smell, Synapses
Animals, Apoptosis, Conditioning (Psychology), Drosophila Proteins, Drosophila melanogaster, Fragile X Mental Retardation Protein, Mass Spectrometry, Memory, Mushroom Bodies, Mutation, Neurons, Phenotype, Post-Synaptic Density, Receptors, Metabotropic Glutamate, Smell, Synapses
Elife
Date: Nov. 13, 2014
PubMed ID: 25392983
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