A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.

The Hippo (Hpo) pathway controls tissue growth and organ size by regulating the activity of transcriptional co-activator Yorkie (Yki), which associates with transcription factor Scalloped (Sd) in the nucleus to promote downstream target gene expression. Here we identify a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding ...
to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity. We also find that SdBP retains Yki in the nucleus through the association with Yki WW domains via its PPXY motifs. Collectively, we identify SdBP as a novel component of the Hpo pathway, negatively regulating the transcriptional activity of Sd-Yki to restrict tissue growth.
Mesh Terms:
Amino Acid Motifs, Animals, Carrier Proteins, Cell Line, Drosophila, Drosophila Proteins, Gene Expression Regulation, Developmental, Intracellular Signaling Peptides and Proteins, Nuclear Proteins, Protein Interaction Maps, Protein Structure, Tertiary, Protein-Serine-Threonine Kinases, Signal Transduction, Trans-Activators, Transcription Factors, Transcriptional Activation, Up-Regulation
Cell Res.
Date: Oct. 01, 2013
Download Curated Data For This Publication
201462
Switch View:
  • Interactions 14