The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis.
In a genetic screen for mutations that restrict cell growth and organ size, we identified a new tumor suppressor gene, dMST, which encodes the Drosophila homolog of the mammalian Ste20 kinase family members MST1 and MST2. Loss-of-function mutations in dMST result in overgrown tissues containing more cells of normal size. ... dMST mutant cells exhibit elevated levels of Cyclin E and DIAP1, increased cell growth and proliferation, and impaired apoptosis. dMST forms a complex with Sav and Wts, two tumor suppressors also implicated in regulating both cell proliferation and apoptosis, suggesting that they act in common pathways.
Mesh Terms:
Amino Acid Sequence, Animals, Apoptosis, Cell Division, Cloning, Molecular, Drosophila, Eye, Molecular Sequence Data, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins
Amino Acid Sequence, Animals, Apoptosis, Cell Division, Cloning, Molecular, Drosophila, Eye, Molecular Sequence Data, Protein-Serine-Threonine Kinases, Tumor Suppressor Proteins
Genes Dev.
Date: Oct. 15, 2003
PubMed ID: 14561774
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