Mus musculus
NKX2-5
Csx, Nkx-2.5, Nkx2.5, tinman
NK2 homeobox 5
GO Process (66)
GO Function (16)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte differentiation [IMP]
- adult heart development [IMP, ISO]
- apoptotic process involved in heart morphogenesis [IMP]
- atrial cardiac muscle cell development [TAS]
- atrial septum morphogenesis [ISO]
- atrioventricular node cell development [IMP]
- atrioventricular node cell fate commitment [IMP]
- atrioventricular node development [IMP]
- bundle of His development [IGI]
- canonical Wnt signaling pathway [IDA]
- cardiac conduction system development [IGI, ISO]
- cardiac muscle cell differentiation [IDA, IGI, IMP, TAS]
- cardiac muscle cell proliferation [IGI]
- cardiac muscle contraction [IMP]
- cardiac muscle tissue development [IMP]
- cardiac muscle tissue morphogenesis [ISO]
- cardiac ventricle formation [IGI]
- cardiac ventricle morphogenesis [IMP]
- cardiovascular system development [IGI]
- cell differentiation [IGI]
- embryonic heart tube development [IGI]
- embryonic heart tube left/right pattern formation [IMP]
- endoderm development [TAS]
- heart contraction [IGI]
- heart development [IGI, IMP]
- heart looping [IMP]
- heart morphogenesis [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- negative regulation of apoptotic process [IGI]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP, ISO]
- negative regulation of myotube differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- outflow tract morphogenesis [IGI, IMP]
- outflow tract septum morphogenesis [ISO]
- pharyngeal system development [IGI]
- positive regulation of cardioblast differentiation [IMP]
- positive regulation of cell proliferation [IGI]
- positive regulation of gene expression [IDA]
- positive regulation of heart contraction [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of sodium ion transport [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription initiation from RNA polymerase II promoter [IDA]
- positive regulation of transcription via serum response element binding [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of voltage-gated calcium channel activity [IMP]
- proepicardium development [IMP]
- pulmonary myocardium development [IMP]
- regulation of cardiac muscle cell proliferation [IDA]
- regulation of cardiac muscle contraction [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- right ventricular cardiac muscle tissue morphogenesis [ISO]
- sarcomere organization [IGI]
- septum secundum development [ISO]
- spleen development [IGI, ISO, TAS]
- thyroid gland development [IMP, ISO]
- tongue development [TAS]
- transcription from RNA polymerase II promoter [IMP]
- vasculogenesis [IMP]
- ventricular cardiac muscle cell development [TAS]
- ventricular cardiac myofibril assembly [IMP]
- ventricular septum morphogenesis [ISO]
- ventricular trabecula myocardium morphogenesis [IMP]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription cofactor activity [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- serum response element binding [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II transcription cofactor activity [IMP]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IMP]
- chromatin binding [IDA, ISO]
- histone deacetylase binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- serum response element binding [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Download Curated Data for this Protein
201778
10090
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- Interactors 12
- Interactions 18
- Network