Mus musculus
PKD2
C030034P18Rik, PC2, TRPP2
polycystic kidney disease 2
GO Process (37)
GO Function (21)
GO Component (21)
Gene Ontology Biological Process
- JAK-STAT cascade [IDA]
- calcium ion transmembrane transport [IDA, ISO]
- calcium ion transport [IMP, ISO]
- cell cycle arrest [IDA]
- cellular calcium ion homeostasis [IMP]
- cellular response to fluid shear stress [IMP, ISO]
- cellular response to hydrostatic pressure [ISO]
- cellular response to osmotic stress [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- detection of mechanical stimulus [IMP]
- detection of nodal flow [IMP]
- determination of left/right symmetry [IMP]
- determination of liver left/right asymmetry [ISO]
- embryonic placenta development [IMP]
- heart development [IMP]
- heart looping [ISO]
- kidney development [IGI, IMP]
- liver development [IGI]
- negative regulation of G1/S transition of mitotic cell cycle [ISO]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- placenta blood vessel development [IMP]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISO]
- positive regulation of nitric oxide biosynthetic process [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- potassium ion transmembrane transport [IDA]
- regulation of cAMP metabolic process [IMP]
- regulation of calcium ion import [ISO]
- regulation of cell proliferation [ISO]
- release of sequestered calcium ion into cytosol [IMP, ISO]
- renal system development [IGI]
- renal tubule morphogenesis [IMP]
- sodium ion transmembrane transport [ISO]
- transmembrane transport [IMP]
Gene Ontology Molecular Function- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
- ATPase binding [IPI]
- HLH domain binding [ISO]
- actinin binding [ISO]
- alpha-actinin binding [ISO]
- calcium channel activity [IDA, TAS]
- calcium ion binding [IDA]
- calcium-induced calcium release activity [ISO]
- channel activity [IMP]
- cytoskeletal protein binding [ISO]
- identical protein binding [IPI, ISO]
- ion channel binding [ISO]
- muscle alpha-actinin binding [ISO]
- phosphoprotein binding [ISO]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated calcium channel activity [ISO]
- voltage-gated cation channel activity [ISO]
- voltage-gated ion channel activity [ISO]
- voltage-gated sodium channel activity [ISO]
Gene Ontology Cellular Component
- basal cortex [IDA, ISO]
- basal plasma membrane [ISO]
- cell-cell junction [IDA]
- ciliary basal body [IDA, ISO]
- cilium [IDA, IMP]
- cytoplasm [IDA, ISO]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP, ISO, TAS]
- endoplasmic reticulum membrane [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- integral component of cytoplasmic side of endoplasmic reticulum membrane [ISO]
- integral component of lumenal side of endoplasmic reticulum membrane [ISO]
- integral component of plasma membrane [ISO]
- lamellipodium [ISO]
- membrane [ISO]
- mitotic spindle [IDA, ISO]
- motile primary cilium [IDA]
- nonmotile primary cilium [IDA]
- plasma membrane [IDA, ISO]
- polycystin complex [IDA]
Download Curated Data for this Protein
202205
10090
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- Interactors 18
- Interactions 22
- Network
- PTM Sites 1