Cabut/dTIEG associates with the transcription factor Yorkie for growth control.
The Drosophila transcription factor Cabut/dTIEG (Cbt) is a growth regulator, whose expression is modulated by different stimuli. Here, we determine Cbt association with chromatin and identify Yorkie (Yki), the transcriptional co-activator of the Hippo (Hpo) pathway as its partner. Cbt and Yki co-localize on common gene promoters, and the expression ... of target genes varies according to changes in Cbt levels. Down-regulation of Cbt suppresses the overgrowth phenotypes caused by mutations in expanded (ex) and yki overexpression, whereas its up-regulation promotes cell proliferation. Our results imply that Cbt is a novel partner of Yki that is required as a transcriptional co-activator in growth control.
Mesh Terms:
Animals, Chromatin Immunoprecipitation, Drosophila, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Juvenile Hormones, Models, Biological, Nuclear Proteins, Protein-Serine-Threonine Kinases, Real-Time Polymerase Chain Reaction, Sequence Analysis, RNA, Signal Transduction, Trans-Activators, Transcription Factors
Animals, Chromatin Immunoprecipitation, Drosophila, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Juvenile Hormones, Models, Biological, Nuclear Proteins, Protein-Serine-Threonine Kinases, Real-Time Polymerase Chain Reaction, Sequence Analysis, RNA, Signal Transduction, Trans-Activators, Transcription Factors
EMBO Rep.
Date: Mar. 01, 2015
PubMed ID: 25572844
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