The Drosophila immune defense against gram-negative infection requires the death protein dFADD.
Drosophila responds to Gram-negative infections by mounting an immune response that depends on components of the IMD pathway. We recently showed that imd encodes a protein with a death domain with high similarity to that of mammalian RIP. Using a two-hybrid screen in yeast, we have isolated the death protein ... dFADD as a molecule that associates with IMD. Our data show that loss of dFADD function renders flies highly susceptible to Gram-negative infections without affecting resistance to Gram-positive bacteria. By genetic analysis we show that dFADD acts downstream of IMD in the pathway that controls inducibility of the antibacterial peptide genes.
Mesh Terms:
Adaptor Proteins, Signal Transducing, Animals, Carrier Proteins, Drosophila, Drosophila Proteins, Fas-Associated Death Domain Protein, Gene Expression Regulation, Gram-Negative Bacterial Infections, Immunity, Signal Transduction
Adaptor Proteins, Signal Transducing, Animals, Carrier Proteins, Drosophila, Drosophila Proteins, Fas-Associated Death Domain Protein, Gene Expression Regulation, Gram-Negative Bacterial Infections, Immunity, Signal Transduction
Immunity
Date: Nov. 01, 2002
PubMed ID: 12433364
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