Mus musculus
RYR2
9330127I20Rik, RYR-2
ryanodine receptor 2, cardiac
GO Process (40)
GO Function (16)
GO Component (21)
Gene Ontology Biological Process
- BMP signaling pathway [IDA]
- Purkinje myocyte to ventricular cardiac muscle cell signaling [IMP]
- calcium ion transmembrane transport [IDA, IMP, ISO]
- calcium ion transport [IDA, IMP, IPI, ISO]
- calcium ion transport into cytosol [ISO]
- calcium-mediated signaling [IMP]
- calcium-mediated signaling using intracellular calcium source [ISO]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle contraction [ISO]
- cardiac muscle hypertrophy [IMP]
- cellular calcium ion homeostasis [IMP]
- cellular response to caffeine [IDA, ISO]
- cytosolic calcium ion homeostasis [ISO]
- cytosolic calcium ion transport [IMP]
- detection of calcium ion [ISO]
- embryonic heart tube morphogenesis [IMP]
- establishment of protein localization to endoplasmic reticulum [ISO]
- ion transmembrane transport [ISO]
- left ventricular cardiac muscle tissue morphogenesis [IMP]
- manganese ion transmembrane transport [ISO]
- negative regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of heart rate [IMP]
- positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction [IMP]
- positive regulation of sequestering of calcium ion [ISO]
- positive regulation of the force of heart contraction [ISO]
- regulation of cardiac muscle contraction [ISO]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IGI]
- regulation of heart rate [IMP, ISO]
- release of sequestered calcium ion into cytosol [ISO]
- release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA, IMP, ISO]
- response to caffeine [IDA, ISO]
- response to calcium ion [ISO]
- response to hypoxia [IDA]
- response to magnesium ion [ISO]
- response to muscle stretch [ISO]
- response to redox state [ISO]
- sarcoplasmic reticulum calcium ion transport [ISO]
- type B pancreatic cell apoptotic process [IMP, ISO]
- ventricular cardiac muscle cell action potential [IMP]
Gene Ontology Molecular Function- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
- calcium channel activity [IDA]
- calcium-induced calcium release activity [ISO]
- calcium-release channel activity [ISO]
- calmodulin binding [IDA, ISO]
- enzyme binding [IPI, ISO]
- identical protein binding [ISO]
- intracellular ligand-gated calcium channel activity [IDA]
- organic cyclic compound binding [IPI]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein kinase binding [IPI]
- protein self-association [IMP]
- ryanodine-sensitive calcium-release channel activity [IDA, ISO]
- scaffold protein binding [ISO]
- suramin binding [ISO]
Gene Ontology Cellular Component
- A band [ISO]
- Z disc [IDA, ISO]
- calcium channel complex [IDA, ISO]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [IMP]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [ISO]
- integral component of membrane [IC]
- intracellular [IGI]
- membrane [IDA, ISO]
- neuron projection [ISO]
- nuclear envelope [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- sarcomere [IDA]
- sarcoplasmic reticulum [IDA, ISO]
- sarcoplasmic reticulum membrane [IDA, ISO]
- smooth endoplasmic reticulum [IDA]
Download Curated Data for this Protein
203046
10090
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- Interactors 23
- Interactions 25
- Network
- PTM Sites 93