Mus musculus
FOXP3
JM2, scurfin, sf, RP23-54C14.1
forkhead box P3
GO Process (52)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- T cell activation [IMP, ISO]
- T cell mediated immunity [IMP]
- T cell receptor signaling pathway [IMP]
- cytokine production [IDA, IGI, IMP]
- myeloid cell homeostasis [IMP]
- negative regulation of CREB transcription factor activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of T cell cytokine production [ISO]
- negative regulation of T cell proliferation [IDA, IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of chronic inflammatory response [IDA, IMP]
- negative regulation of cytokine biosynthetic process [ISO]
- negative regulation of cytokine secretion [ISO]
- negative regulation of histone acetylation [IDA]
- negative regulation of histone deacetylation [ISO]
- negative regulation of immune response [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of interferon-gamma biosynthetic process [IDA]
- negative regulation of interferon-gamma production [IDA, IMP, ISO]
- negative regulation of interleukin-10 production [IMP, ISO]
- negative regulation of interleukin-2 biosynthetic process [IDA, ISO]
- negative regulation of interleukin-2 production [IDA, ISO]
- negative regulation of interleukin-4 production [IDA, IMP, ISO]
- negative regulation of interleukin-5 production [IDA, IMP]
- negative regulation of interleukin-6 production [IMP]
- negative regulation of isotype switching to IgE isotypes [IMP]
- negative regulation of lymphocyte proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [IMP]
- positive regulation of T cell anergy [IMP]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of gene expression [IDA]
- positive regulation of histone acetylation [IDA, ISO]
- positive regulation of immature T cell proliferation in thymus [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of peripheral T cell tolerance induction [IMP]
- positive regulation of regulatory T cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta1 production [IDA]
- regulation of immunoglobulin production [IMP]
- regulation of isotype switching to IgG isotypes [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulatory T cell differentiation [IDA, IMP]
- tolerance induction [IDA]
- tolerance induction to self antigen [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
- NFAT protein binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription corepressor activity [IDA]
Download Curated Data for this Protein
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- Interactors 372
- Interactions 392
- Chemical Interactions 1
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