Interaction of short-range repressors with Drosophila CtBP in the embryo.

Human CtBP attenuates transcriptional activation and tumorigenesis mediated by the adenovirus E1A protein. The E1A sequence motif that interacts with CtBP, Pro-X-Asp-Leu-Ser-X-Lys (P-DLS-K), is present in the repression domains of two unrelated short-range repressors in Drosophila, Knirps and Snail, and is essential for the interaction of these proteins with Drosophila ...
CtBP (dCtBP). A P-element-induced mutation in dCtBP exhibits gene-dosage interactions with a null mutation in knirps, which is consistent with the occurrence of Knirps-dCtBP interactions in vivo. These observations suggest that CtBP and dCtBP are engaged in an evolutionarily conserved mechanism of transcriptional repression, which is used in both Drosophila and mammals.
Mesh Terms:
Alcohol Oxidoreductases, Amino Acid Sequence, Animals, Animals, Genetically Modified, Cell Nucleus, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Embryo, Nonmammalian, Female, Gene Dosage, Gene Expression Regulation, Genes, Insect, Genes, Reporter, Humans, Insect Proteins, Male, Molecular Sequence Data, Mutation, Phosphoproteins, Recombinant Fusion Proteins, Repressor Proteins, Snail Family Transcription Factors, Transcription Factors, Transcription, Genetic
Science
Date: Apr. 03, 1998
Download Curated Data For This Publication
203422
Switch View:
  • Interactions 4