Mus musculus
TEK
AA517024, Cd202b, Hyk, STK1, Tie-2, Tie2, RP23-345A23.1
endothelial-specific receptor tyrosine kinase
GO Process (42)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
- Tie signaling pathway [ISO, TAS]
- angiogenesis [IMP, TAS]
- cell-matrix adhesion [IMP]
- endothelial cell proliferation [IMP]
- heart development [IMP]
- heart trabecula formation [IMP]
- hemopoiesis [IMP]
- intracellular signal transduction [ISO]
- negative regulation of angiogenesis [ISO]
- negative regulation of apoptotic process [IGI]
- negative regulation of endothelial cell apoptotic process [IMP]
- patterning of blood vessels [TAS]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cytokine secretion involved in immune response [IDA]
- positive regulation of endothelial cell migration [ISO, TAS]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein import into nucleus [IDA]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [TAS]
- protein autophosphorylation [ISO]
- protein oligomerization [ISO]
- regulation of NIK/NF-kappaB signaling [IGI]
- regulation of angiogenesis [IMP]
- regulation of cell migration [IDA, IMP]
- regulation of endothelial cell proliferation [TAS]
- regulation of establishment or maintenance of cell polarity [ISO]
- response to estrogen [ISO]
- response to retinoic acid [IDA]
- single organismal cell-cell adhesion [IMP]
- sprouting angiogenesis [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin filament [ISO]
- apical plasma membrane [ISO]
- basal plasma membrane [ISO]
- basolateral plasma membrane [ISO]
- cell surface [ISO]
- cell-cell junction [ISO]
- integral component of membrane [ISM]
- integral component of plasma membrane [ISO]
- membrane raft [ISO]
- microvillus [ISO]
- perinuclear region of cytoplasm [IDA]
- stress fiber [ISO]
Download Curated Data for this Protein
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10090
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- Interactors 5
- Interactions 12
- Network