A multiprotein complex that interacts with RNA polymerase II elongator.
A three-subunit Hap complex that interacts with the RNA polymerase II Elongator was isolated from yeast. Deletions of genes for two Hap subunits, HAP1 and HAP3, confer pGKL killer-insensitive and weak Elongator phenotypes. Preferential interaction of the Hap complex with free rather than RNA polymerase II-associated Elongator suggests a role ... in the regulation of Elongator activity.
Mesh Terms:
Amino Acid Sequence, CCAAT-Binding Factor, Carbon-Oxygen Lyases, DNA-(Apurinic or Apyrimidinic Site) Lyase, Electrophoresis, Polyacrylamide Gel, Fungal Proteins, Models, Biological, Molecular Sequence Data, Mutation, Phenotype, Phosphorylation, Precipitin Tests, Protein Binding, RNA Polymerase II, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Transcription Factors
Amino Acid Sequence, CCAAT-Binding Factor, Carbon-Oxygen Lyases, DNA-(Apurinic or Apyrimidinic Site) Lyase, Electrophoresis, Polyacrylamide Gel, Fungal Proteins, Models, Biological, Molecular Sequence Data, Mutation, Phenotype, Phosphorylation, Precipitin Tests, Protein Binding, RNA Polymerase II, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Transcription Factors
J. Biol. Chem.
Date: Aug. 10, 2001
PubMed ID: 11390369
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